Demashita! Powerpuff Girls Z (出ましたっ!パワパフガールズZ, Demashita! Pawapafu Gāruzu Zetto, roughly They're Here! Powerpuff Girls Z) is the name for a Japaneseanime based upon the American animated television series television The Powerpuff Girls.

The anime is produced by Cartoon Network, Toei Animation, and Aniplex; with Yoshiya Ayugai and Mark Buhaj of Cartoon Network, Hiromi Seki, Hideo Katsumata producing, Hiroyuki Kakudou directing and Miho Shimogasa (of Sailor Moon fame) doing character design. As production occurs in Japan, Craig McCracken, the original creator of The Powerpuff Girls, is not directly involved in this project.

The series, an anime reimagining of The Powerpuff Girls, debuted in Japan on July 1, 2006, on TV Tokyo, where the Japanese version of the original Powerpuff Girls premiered, as well as its affiliates, replacing Sugar Sugar Rune in its time slot, Saturday at 7:00 a.m. JST. Its final episode aired on June 30, 2007. Its time was replaced by Fight Tension School on July 7, 2007. Since August 1, 2006, it has also aired on AT-X. Since April 1, 2007, the program airs on Cartoon Network in Japan.

The initial order was for about 52 episodes at 30 minutes each. Recently, Nami Miyahara, the voice actress of Miyako and Bubbles, posted an entry on her blog in which she mentions working with the staff and cast of the series after having not worked on the series for so long. As to whether or not this is referring to more episodes, an OVA, or a movie being produced is currently unknown. Cartoon Network has said it will be showing the anime worldwide. Taiwan became the first country to air the show outside Japan when the show aired there on January 21, 2008. The Ocean Group has also dubbed the official English version of the show and has been shown on several English-speaking markets; it is unknown when the show will make its appearance in the United States. A Latin-American dub premiered on August 2, 2008, although a pre-premiere was done on July 13, 2008. Most of the original dubbing cast returned to reprise their roles. Except in episode 41, none of the voices from the Japanese dub of the original Powerpuff Girls returned to reprise their roles for this series. Kazuki Kosakai was the sole exception, and guest-starred as the narrator. His voice is heard at the end of first part of episode 41. The show is scheduled to appear in Australia in November.

The manga of the same name was introduced in the August 2006 issue of Ribon, published in July 3, 2006.